KCNIP2

Gene Information

Official Symbol: KCNIP2
Official Name: potassium voltage-gated channel interacting protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 30819
UniProt: Q9NS61
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6027
Expression level (log2 read counts): 0.69

Expression Distribution

ER retention sequence binding
positive regulation of potassium ion export across plasma membrane
clustering of voltage-gated potassium channels
A-type (transient outward) potassium channel activity
potassium channel complex
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
regulation of potassium ion export across plasma membrane
neuronal ion channel clustering
detection of calcium ion
potassium ion export across plasma membrane
positive regulation of voltage-gated potassium channel activity
membrane repolarization during cardiac muscle cell action potential
membrane repolarization during action potential
cardiac muscle cell membrane repolarization
membrane repolarization
positive regulation of potassium ion transmembrane transporter activity
neuron maturation
positive regulation of potassium ion transmembrane transport
export across plasma membrane
potassium channel regulator activity
positive regulation of potassium ion transport
cardiac muscle cell action potential
regulation of potassium ion transmembrane transporter activity
positive regulation of cation channel activity
regulation of potassium ion transmembrane transport
voltage-gated potassium channel complex
cardiac conduction
action potential
regulation of potassium ion transport
positive regulation of ion transmembrane transporter activity
protein N-terminus binding
positive regulation of transporter activity
ion channel binding
multicellular organismal signaling
anatomical structure maturation
positive regulation of cation transmembrane transport
response to calcium ion
positive regulation of ion transmembrane transport
cell maturation
potassium ion transmembrane transport