KCNMB4

Official Symbol: KCNMB4
Official Name: potassium calcium-activated channel subfamily M regulatory beta subunit 4
Aliases and Previous Symbols: N/A
Entrez ID: 27345
UniProt: Q86W47
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10792058, ECO:0000269|PubMed:10828459}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

detection of calcium ion
calcium-activated potassium channel activity
neuronal action potential
potassium channel regulator activity
transmission of nerve impulse
regulation of vasoconstriction
voltage-gated potassium channel complex
action potential
regulation of neurotransmitter secretion
multicellular organismal signaling
regulation of blood vessel diameter
regulation of tube diameter
regulation of tube size
regulation of neurotransmitter transport
response to calcium ion
potassium ion transmembrane transport
potassium ion transport
vascular process in circulatory system
regulation of blood circulation
regulation of neurotransmitter levels
response to metal ion
blood circulation
circulatory system process
monovalent inorganic cation transport
chemical synaptic transmission
anterograde trans-synaptic signaling
regulation of membrane potential
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
synaptic signaling
regulation of anatomical structure size
detection of chemical stimulus
response to inorganic substance
inorganic cation transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
detection of stimulus