KHSRP [The Human Chemical-Genetic Interaction Map Project]

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======= KHSRP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KHSRP
  * **<color #00a2e8>Official Name</color>**: KH-type splicing regulatory protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8570|8570]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92945|Q92945]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KHSRP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KHSRP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KH 1|
|DUF1897|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of low-density lipoprotein particle clearance|
|negative regulation of lipoprotein particle clearance|
|regulation of miRNA metabolic process|
|regulation of low-density lipoprotein particle clearance|
|negative regulation of nitric oxide biosynthetic process|
|negative regulation of nitric oxide metabolic process|
|3-UTR-mediated mRNA destabilization|
|regulation of lipoprotein particle clearance|
|exosome (RNase complex)|
|miRNA metabolic process|
|mRNA 3-UTR AU-rich region binding|
|negative regulation of reactive oxygen species biosynthetic process|
|mRNA destabilization|
|RNA destabilization|
|positive regulation of mRNA catabolic process|
|negative regulation of reactive oxygen species metabolic process|
|regulation of nitric oxide biosynthetic process|
|cytoplasmic stress granule|
|positive regulation of mRNA metabolic process|
|regulation of reactive oxygen species biosynthetic process|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|mRNA transport|
|regulation of reactive oxygen species metabolic process|
|regulation of mRNA stability|
|regulation of RNA stability|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|regulation of mRNA catabolic process|
|mRNA catabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|RNA catabolic process|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|regulation of translation|
|regulation of neurotransmitter levels|
|positive regulation of cellular catabolic process|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ncRNA metabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.81|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.89|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1800
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KHSRP Expression in NALM6 Cells: 8.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>