KHSRP

Gene Information

Official Symbol: KHSRP
Official Name: KH-type splicing regulatory protein
Aliases and Previous Symbols: N/A
Entrez ID: 8570
UniProt: Q92945
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1800
Expression level (log2 read counts): 8.7

Expression Distribution

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	1.81
BI-D1870 3.15μM R02 exp66	1.89
Alda-1 10μM R06 exp262	1.99

KH 1
DUF1897

negative regulation of low-density lipoprotein particle clearance
negative regulation of lipoprotein particle clearance
regulation of miRNA metabolic process
regulation of low-density lipoprotein particle clearance
negative regulation of nitric oxide biosynthetic process
negative regulation of nitric oxide metabolic process
3-UTR-mediated mRNA destabilization
regulation of lipoprotein particle clearance
exosome (RNase complex)
miRNA metabolic process
mRNA 3-UTR AU-rich region binding
negative regulation of reactive oxygen species biosynthetic process
mRNA destabilization
RNA destabilization
positive regulation of mRNA catabolic process
negative regulation of reactive oxygen species metabolic process
regulation of nitric oxide biosynthetic process
cytoplasmic stress granule
positive regulation of mRNA metabolic process
regulation of reactive oxygen species biosynthetic process
negative regulation of translation
negative regulation of cellular amide metabolic process
mRNA transport
regulation of reactive oxygen species metabolic process
regulation of mRNA stability
regulation of RNA stability
nucleic acid transport
RNA transport
establishment of RNA localization
regulation of mRNA catabolic process
mRNA catabolic process
RNA localization
nucleobase-containing compound transport
RNA catabolic process
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
regulation of translation
regulation of neurotransmitter levels
positive regulation of cellular catabolic process
nucleobase-containing compound catabolic process