KIAA0226L

Entrez Summary: This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017].
UniProt Summary: May act as a tumor suppressor. {ECO:0000269|PubMed:23522960}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

autophagosome-lysosome fusion
autophagosome-endosome fusion
phosphatidylinositol-5-phosphate binding
phosphatidylinositol-4-phosphate binding
autophagosome membrane
autophagosome maturation
regulation of glycogen metabolic process
phosphatidylinositol-3-phosphate binding
regulation of polysaccharide metabolic process
vesicle fusion
organelle membrane fusion
organelle fusion
regulation of glucose metabolic process
membrane fusion
regulation of cellular carbohydrate metabolic process
regulation of generation of precursor metabolites and energy
macroautophagy
regulation of carbohydrate metabolic process
protein-containing complex disassembly
cytoplasmic vesicle
process utilizing autophagic mechanism
autophagy
vesicle organization
regulation of lipid metabolic process
cellular component disassembly
regulation of small molecule metabolic process
membrane organization
lipid metabolic process
cellular catabolic process
protein-containing complex subunit organization
vesicle-mediated transport