KIAA0922 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA0922 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM131L
  * **<color #00a2e8>Official Name</color>**: transmembrane 131 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23240|23240]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A2VDJ0|A2VDJ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA0922&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA0922|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616243|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000269|PubMed:23690469}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3651|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of immature T cell proliferation in thymus|
|negative regulation of immature T cell proliferation|
|regulation of immature T cell proliferation in thymus|
|negative regulation of T cell differentiation in thymus|
|regulation of immature T cell proliferation|
|regulation of T cell differentiation in thymus|
|negative regulation of T cell differentiation|
|negative regulation of lymphocyte differentiation|
|negative regulation of T cell proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|negative regulation of leukocyte differentiation|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|regulation of T cell proliferation|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of canonical Wnt signaling pathway|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|negative regulation of Wnt signaling pathway|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of canonical Wnt signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|regulation of cell-cell adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|negative regulation of developmental process|
|endoplasmic reticulum|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-4.45|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.97|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.92|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.67|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.52|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.11|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.91|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.87|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.82|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.76|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.79|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.12|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tmem39a|TMEM39A]]|0.621|
|[[:human genes:p:p4hb|P4HB]]|0.527|
|[[:human genes:u:ufm1|UFM1]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA0922 Expression in NALM6 Cells: 8.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>