KIAA0922

Gene Information

Official Symbol: TMEM131L
Official Name: transmembrane 131 like
Aliases and Previous Symbols: N/A
Entrez ID: 23240
UniProt: A2VDJ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000269|PubMed:23690469}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-4.45
Golgicide-A 4μM R03 exp122	-2.97
Aminopterin 0.005μM R07 exp335	-2.92
Thapsigargin 0.005μM R07 exp407	-2.67
Tubacin 1.6μM R07 exp416	-2.52
3-Bromopyruvate 7μM R04 exp175	-2.11
Rapamycin 0.001μM R08 exp429	-1.91
Olaparib 4μM R08 exp512	-1.87
Q15 2.7μM R02 exp79	-1.82
Trimetrexate 0.03μM R08 exp535	1.76
Citral 50μM R06 exp274	1.79
Hypoxia 5%O2 R04 exp191	2.12
iCRT14 30μM R08 exp492	2.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17654
Expression level (log2 read counts): 8.29

Expression Distribution

Gene	Correlation
TMEM39A	0.621
P4HB	0.527
UFM1	0.431

negative regulation of immature T cell proliferation in thymus
negative regulation of immature T cell proliferation
regulation of immature T cell proliferation in thymus
negative regulation of T cell differentiation in thymus
regulation of immature T cell proliferation
regulation of T cell differentiation in thymus
negative regulation of T cell differentiation
negative regulation of lymphocyte differentiation
negative regulation of T cell proliferation
negative regulation of mononuclear cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of leukocyte proliferation
negative regulation of leukocyte differentiation
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
negative regulation of hemopoiesis
regulation of T cell differentiation
negative regulation of lymphocyte activation
regulation of T cell proliferation
regulation of lymphocyte differentiation
negative regulation of cell-cell adhesion
negative regulation of leukocyte activation
negative regulation of canonical Wnt signaling pathway
negative regulation of cell activation
regulation of lymphocyte proliferation
negative regulation of Wnt signaling pathway
regulation of mononuclear cell proliferation
regulation of leukocyte proliferation
regulation of leukocyte differentiation
negative regulation of cell adhesion
regulation of canonical Wnt signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
regulation of cell-cell adhesion
cell surface receptor signaling pathway involved in cell-cell signaling
negative regulation of immune system process
regulation of hemopoiesis