KIAA2022 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA2022 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEXMIF
  * **<color #00a2e8>Official Name</color>**: neurite extension and migration factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340533|340533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5QGS0|Q5QGS0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA2022&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA2022|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300524|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  An inversion on the X chromosome which disrupts this gene and a G-protein coupled purinergic receptor gene located in the pseudoautosomal region of the X chromosome has been linked to X linked cognitive disability.[provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). {ECO:0000250|UniProtKB:D3ZGX1}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell-cell adhesion mediated by cadherin|
|negative regulation of cell adhesion mediated by integrin|
|negative regulation of neuron migration|
|regulation of cell-cell adhesion mediated by cadherin|
|negative regulation of cell-matrix adhesion|
|regulation of neuron migration|
|regulation of cell adhesion mediated by integrin|
|negative regulation of cell-substrate adhesion|
|regulation of cell-matrix adhesion|
|negative regulation of cell-cell adhesion|
|regulation of cell-substrate adhesion|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|regulation of cell-cell adhesion|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of multicellular organismal process|
|generation of neurons|
|neurogenesis|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.12|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.95|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.88|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.77|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.92|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13620
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA2022 Expression in NALM6 Cells: 0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>