KIAA2022

Entrez Summary: An inversion on the X chromosome which disrupts this gene and a G-protein coupled purinergic receptor gene located in the pseudoautosomal region of the X chromosome has been linked to X linked cognitive disability.[provided by RefSeq, Mar 2009].
UniProt Summary: Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1). {ECO:0000250|UniProtKB:D3ZGX1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of cell adhesion mediated by integrin
negative regulation of neuron migration
regulation of cell-cell adhesion mediated by cadherin
negative regulation of cell-matrix adhesion
regulation of neuron migration
regulation of cell adhesion mediated by integrin
negative regulation of cell-substrate adhesion
regulation of cell-matrix adhesion
negative regulation of cell-cell adhesion
regulation of cell-substrate adhesion
negative regulation of cell migration
negative regulation of cell adhesion
negative regulation of cell motility
negative regulation of neurogenesis
negative regulation of cellular component movement
negative regulation of nervous system development
negative regulation of locomotion
negative regulation of cell development
regulation of cell-cell adhesion
regulation of cell adhesion
negative regulation of cell differentiation
regulation of neurogenesis
regulation of cell migration
regulation of cell motility
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
regulation of locomotion
regulation of cellular component movement
negative regulation of multicellular organismal process
generation of neurons
neurogenesis
regulation of cell differentiation