KIF1A

Entrez Summary: The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anterograde neuronal dense core vesicle transport
interkinetic nuclear migration
retrograde neuronal dense core vesicle transport
dense core granule cytoskeletal transport
dense core granule transport
dense core granule localization
secretory granule localization
retrograde axonal transport
nuclear migration
ATP-dependent microtubule motor activity, plus-end-directed
nucleus localization
cell proliferation in forebrain
anterograde axonal transport
vesicle transport along microtubule
motor activity
vesicle cytoskeletal trafficking
kinesin complex
axonal transport
axon cytoplasm
axo-dendritic transport
protein transport along microtubule
microtubule-based protein transport
microtubule motor activity
neural precursor cell proliferation
organelle transport along microtubule
postsynapse
synaptic vesicle
cytosolic transport
transport along microtubule
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
vesicle localization
ATPase activity
microtubule binding
microtubule-based movement
axon
microtubule
neuron projection
establishment of organelle localization