KIF1C [The Human Chemical-Genetic Interaction Map Project]

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======= KIF1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF1C
  * **<color #00a2e8>Official Name</color>**: kinesin family member 1C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10749|10749]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43896|O43896]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility. {ECO:0000269|PubMed:9685376}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anterograde neuronal dense core vesicle transport|
|retrograde neuronal dense core vesicle transport|
|dense core granule cytoskeletal transport|
|dense core granule transport|
|dense core granule localization|
|secretory granule localization|
|retrograde axonal transport|
|ATP-dependent microtubule motor activity, plus-end-directed|
|anterograde axonal transport|
|vesicle transport along microtubule|
|motor activity|
|vesicle cytoskeletal trafficking|
|kinesin complex|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|microtubule motor activity|
|organelle transport along microtubule|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|cytosolic transport|
|transport along microtubule|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|vesicle localization|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|axon|
|microtubule|
|neuron projection|
|establishment of organelle localization|
|Golgi vesicle transport|
|dendrite|
|organelle localization|
|microtubule-based process|
|Golgi apparatus|
|endoplasmic reticulum|
|RNA binding|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8104
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF1C Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>