KIF1C

Entrez Summary: The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014].
UniProt Summary: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility. {ECO:0000269|PubMed:9685376}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anterograde neuronal dense core vesicle transport
retrograde neuronal dense core vesicle transport
dense core granule cytoskeletal transport
dense core granule transport
dense core granule localization
secretory granule localization
retrograde axonal transport
ATP-dependent microtubule motor activity, plus-end-directed
anterograde axonal transport
vesicle transport along microtubule
motor activity
vesicle cytoskeletal trafficking
kinesin complex
axonal transport
axon cytoplasm
axo-dendritic transport
microtubule motor activity
organelle transport along microtubule
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
cytosolic transport
transport along microtubule
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
vesicle localization
ATPase activity
microtubule binding
microtubule-based movement
axon
microtubule
neuron projection
establishment of organelle localization
Golgi vesicle transport
dendrite
organelle localization
microtubule-based process
Golgi apparatus
endoplasmic reticulum
RNA binding
ATP binding