KIF2B

Entrez Summary: N/A
UniProt Summary: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity (PubMed:17538014). Plays a role in chromosome congression (PubMed:23891108). {ECO:0000269|PubMed:17538014, ECO:0000269|PubMed:23891108}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microtubule depolymerization
protein depolymerization
microtubule polymerization or depolymerization
kinesin complex
metaphase plate congression
intercellular bridge
microtubule motor activity
establishment of chromosome localization
chromosome localization
mitotic spindle
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
condensed chromosome kinetochore
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
regulation of chromosome segregation
cellular protein complex disassembly
microtubule cytoskeleton
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
nuclear chromosome segregation
ATPase activity
microtubule binding
protein-containing complex disassembly
microtubule-based movement
chromosome segregation
microtubule
establishment of organelle localization
Golgi vesicle transport
cellular component disassembly
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
cell division
organelle localization
microtubule-based process
nucleolus
cell cycle process