KIF3A

Entrez Summary: N/A
UniProt Summary: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

kinesin II complex
plus-end-directed vesicle transport along microtubule
plus-end-directed organelle transport along microtubule
microtubule anchoring at centrosome
centriole-centriole cohesion
microtubule anchoring at microtubule organizing center
protein localization to cell junction
microtubule anchoring
ATP-dependent microtubule motor activity, plus-end-directed
spectrin binding
spindle microtubule
intraciliary transport involved in cilium assembly
anterograde axonal transport
vesicle transport along microtubule
ciliary tip
vesicle cytoskeletal trafficking
intraciliary transport
kinesin complex
axonal transport
axon cytoplasm
axo-dendritic transport
protein transport along microtubule
microtubule-based protein transport
microtubule motor activity
organelle transport along microtubule
centrosome cycle
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
protein phosphatase binding
microtubule organizing center organization
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
centriole
Rab GTPase binding
microtubule cytoskeleton
transport along microtubule
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
antigen processing and presentation of exogenous peptide antigen
microtubule-based transport