KIF4B

Entrez Summary: N/A
UniProt Summary: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitotic spindle midzone assembly
mitotic spindle elongation
spindle elongation
spindle midzone assembly
mitotic spindle assembly
kinesin complex
intercellular bridge
microtubule motor activity
mitotic cytokinesis
mitotic spindle organization
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
cytoskeleton-dependent cytokinesis
antigen processing and presentation of exogenous peptide antigen via MHC class II
cytokinesis
spindle assembly
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
microtubule cytoskeleton organization involved in mitosis
mitotic sister chromatid segregation
nuclear matrix
sister chromatid segregation
mitotic nuclear division
spindle organization
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
nuclear chromosome segregation
ATPase activity
microtubule binding
microtubule-based movement
chromosome segregation
nuclear division
organelle fission
microtubule
Golgi vesicle transport
microtubule cytoskeleton organization
cell division
mitotic cell cycle process
microtubule-based process