KLF10

Entrez Summary: This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
UniProt Summary: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. {ECO:0000250|UniProtKB:O89091, ECO:0000269|PubMed:8584037}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.73
SGC2096 2.6μM R03 exp153	1.87

core promoter sequence-specific DNA binding
positive regulation of osteoclast differentiation
bone mineralization
positive regulation of myeloid leukocyte differentiation
somatic stem cell population maintenance
regulation of osteoclast differentiation
positive regulation of myeloid cell differentiation
biomineralization
biomineral tissue development
regulation of circadian rhythm
regulation of myeloid leukocyte differentiation
stem cell population maintenance
maintenance of cell number
circadian rhythm
positive regulation of leukocyte differentiation
cellular response to starvation
positive regulation of hemopoiesis
response to starvation
regulation of myeloid cell differentiation
cellular response to nutrient levels
ossification
cellular response to extracellular stimulus
regulation of leukocyte differentiation
rhythmic process
cellular response to peptide
cellular response to external stimulus
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of hemopoiesis
response to peptide
response to nutrient levels
RNA polymerase II proximal promoter sequence-specific DNA binding
response to extracellular stimulus
cellular response to organonitrogen compound
cellular response to nitrogen compound
negative regulation of cell population proliferation
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
positive regulation of cell differentiation
response to organonitrogen compound
cellular response to oxygen-containing compound