KLF11

Entrez Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010].
UniProt Summary: Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Arsenate 40μM R06 exp264	-1.79
CFI-400945 25μM R08 exp469	-1.73

regulation of transcription involved in G1/S transition of mitotic cell cycle
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
transcription regulatory region DNA binding
mitotic cell cycle phase transition
cell cycle phase transition
nuclear body
cellular response to peptide
focal adhesion
response to peptide
transcription by RNA polymerase II
mitotic cell cycle process
cellular response to organonitrogen compound
transcription, DNA-templated
nucleic acid-templated transcription
positive regulation of apoptotic process
positive regulation of programmed cell death
RNA biosynthetic process
cellular response to nitrogen compound
negative regulation of cell population proliferation
DNA-binding transcription factor activity
mitotic cell cycle
positive regulation of cell death
negative regulation of transcription by RNA polymerase II
apoptotic process
cell cycle process
response to organonitrogen compound
programmed cell death
cellular response to oxygen-containing compound
response to nitrogen compound
cell death
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
cellular response to endogenous stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process