KLF5
Gene Information
- Official Symbol: KLF5
- Official Name: Kruppel like factor 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 688
- UniProt: Q13887
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
Pfam Domains GO Terms
Pfam Domains
| zf-C2H2 |
GO Terms
| satellite cell activation involved in skeletal muscle regeneration |
| cell-cell signaling via exosome |
| positive regulation of transcription by transcription factor localization |
| skeletal muscle satellite cell activation |
| MRF binding |
| skeletal muscle satellite cell differentiation |
| regulation of microvillus assembly |
| myotube differentiation involved in skeletal muscle regeneration |
| intestinal epithelial cell development |
| regulation of microvillus organization |
| microvillus assembly |
| microvillus organization |
| intestinal epithelial cell differentiation |
| positive regulation of pri-miRNA transcription by RNA polymerase II |
| skeletal muscle tissue regeneration |
| regulation of pri-miRNA transcription by RNA polymerase II |
| columnar/cuboidal epithelial cell development |
| skeletal muscle cell differentiation |
| myotube differentiation |
| positive regulation of fat cell differentiation |
| tissue regeneration |
| columnar/cuboidal epithelial cell differentiation |
| response to leukemia inhibitory factor |
| cellular response to leukemia inhibitory factor |
| regulation of fat cell differentiation |
| skeletal muscle tissue development |
| digestive tract development |
| skeletal muscle organ development |
| digestive system development |
| regeneration |
| epithelial cell development |
| regulation of plasma membrane bounded cell projection assembly |
| striated muscle cell differentiation |
| regulation of cell projection assembly |
| transcription factor complex |
| muscle cell differentiation |
| striated muscle tissue development |
| muscle organ development |
| muscle tissue development |
| angiogenesis |
| cellular response to peptide |
| developmental growth |
| growth |
| blood vessel morphogenesis |
| plasma membrane bounded cell projection assembly |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| cell projection assembly |
| response to peptide |
| muscle structure development |
| wound healing |
| transcription by RNA polymerase II |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| cellular response to organic cyclic compound |
| response to wounding |
| cellular response to organonitrogen compound |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| tube morphogenesis |
| cellular response to nitrogen compound |
| epithelial cell differentiation |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| Golgi apparatus |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| OICR-9429 10μM R03 exp142 | -1.75 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RUVBL2 | 0.414 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 52/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 5/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 5/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 5/75 |
| lymphocyte | 0/16 |
| ovary | 4/26 |
| pancreas | 5/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 5/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17090
- Expression level (log2 read counts): 1.78
Expression Distribution
KLF5 Expression in NALM6 Cells: 1.78
