KLHL15

Gene Information

Official Symbol: KLHL15
Official Name: kelch like family member 15
Aliases and Previous Symbols: N/A
Entrez ID: 80311
UniProt: Q96M94
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. [provided by RefSeq, Apr 2009].
UniProt Summary: Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA- end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non- homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354). {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:23135275, ECO:0000269|PubMed:27561354}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15854
Expression level (log2 read counts): 5.71

Expression Distribution

Kelch 1
BTB
BACK

nuclear protein quality control by the ubiquitin-proteasome system
negative regulation of double-strand break repair via homologous recombination
cellular response to misfolded protein
response to misfolded protein
protein quality control for misfolded or incompletely synthesized proteins
negative regulation of double-strand break repair
negative regulation of DNA repair
Cul3-RING ubiquitin ligase complex
negative regulation of DNA recombination
regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
regulation of DNA recombination
negative regulation of DNA metabolic process
regulation of DNA repair
cellular response to topologically incorrect protein
response to topologically incorrect protein
regulation of response to DNA damage stimulus
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of DNA metabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of cellular response to stress
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
negative regulation of nucleobase-containing compound metabolic process
regulation of response to stress
negative regulation of response to stimulus
cellular response to stress
organic substance catabolic process