KLHL40

Gene Information

Official Symbol: KLHL40
Official Name: kelch like family member 40
Aliases and Previous Symbols: N/A
Entrez ID: 131377
UniProt: Q2TBA0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein containing a BACK domain, a BTB/POZ domain, and 5 Kelch repeats, however, its exact function is not known. The gene and the multi-domain protein structure are conserved across different taxa, including primates, rodents, chicken and zebrafish. [provided by RefSeq, Dec 2012].
UniProt Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549). The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity). {ECO:0000250|UniProtKB:Q9D783, ECO:0000269|PubMed:23746549}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14448
Expression level (log2 read counts): -6.6

Expression Distribution

BACK
Kelch 1
BTB

skeletal muscle fiber differentiation
A band
I band
skeletal muscle fiber development
myotube cell development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cul3-RING ubiquitin ligase complex
negative regulation of ubiquitin-dependent protein catabolic process
skeletal muscle cell differentiation
myotube differentiation
negative regulation of proteasomal protein catabolic process
muscle fiber development
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein modification by small protein conjugation or removal
negative regulation of cellular protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
positive regulation of protein ubiquitination
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
skeletal muscle tissue development
skeletal muscle organ development
negative regulation of protein catabolic process
positive regulation of protein modification by small protein conjugation or removal
striated muscle cell development
positive regulation of cellular protein catabolic process
muscle cell development
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
striated muscle cell differentiation
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of protein modification by small protein conjugation or removal
muscle cell differentiation
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
striated muscle tissue development