KLHL6

Gene Information
  • Official Symbol: KLHL6
  • Official Name: kelch like family member 6
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 89857
  • UniProt: Q8WZ60
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
  • UniProt Summary: Involved in B-lymphocyte antigen receptor signaling and germinal center formation. {ECO:0000250}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 12675
  • Expression level (log2 read counts): 6.42

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1