KLK4
Gene Information
- Official Symbol: KLK4
- Official Name: kallikrein related peptidase 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 9622
- UniProt: Q9Y5K2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014].
- UniProt Summary: Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). {ECO:0000250|UniProtKB:Q9Z0M1, ECO:0000269|PubMed:15235027}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7422
- Expression level (log2 read counts): -1.33
KLK4 Expression in NALM6 Cells: -1.33
