KLK8
Gene Information
- Official Symbol: KLK8
- Official Name: kallikrein related peptidase 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 11202
- UniProt: O60259
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Trypsin |
GO Terms
| serine protease inhibitor complex |
| negative regulation of myelination |
| keratinocyte proliferation |
| negative regulation of axon regeneration |
| negative regulation of neuron projection regeneration |
| negative regulation of nervous system process |
| regulation of axon regeneration |
| regulation of neuron projection regeneration |
| regulation of myelination |
| negative regulation of response to wounding |
| secretory granule |
| epithelial cell proliferation |
| memory |
| regulation of nervous system process |
| negative regulation of neuron projection development |
| serine-type endopeptidase activity |
| regulation of response to wounding |
| negative regulation of cell projection organization |
| regulation of synapse organization |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| learning or memory |
| synapse organization |
| negative regulation of neurogenesis |
| cognition |
| negative regulation of nervous system development |
| negative regulation of cell development |
| negative regulation of response to external stimulus |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell part morphogenesis |
| cell population proliferation |
| response to wounding |
| behavior |
| regulation of system process |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of cellular response to stress |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| neuron differentiation |
| cell death |
| regulation of response to external stimulus |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| proteolysis |
| nervous system process |
| regulation of response to stress |
| generation of neurons |
| extracellular space |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of cell differentiation |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.44 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10928
- Expression level (log2 read counts): -7.68
Expression Distribution
KLK8 Expression in NALM6 Cells: -7.68
