KRT17

Entrez Summary: This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	1/5

Expression Distribution

MHC class II protein binding
MHC class II receptor activity
positive regulation of hair follicle development
positive regulation of hair cycle
regulation of hair follicle development
intermediate filament organization
hair follicle morphogenesis
regulation of hair cycle
epidermis morphogenesis
cell periphery
positive regulation of epidermis development
intermediate filament cytoskeleton
intermediate filament cytoskeleton organization
intermediate filament-based process
hair follicle development
skin epidermis development
molting cycle process
hair cycle process
regulation of epidermis development
hair cycle
molting cycle
structural constituent of cytoskeleton
cornification
intermediate filament
positive regulation of translation
positive regulation of cellular amide metabolic process
positive regulation of cell growth
keratinization
positive regulation of growth
keratinocyte differentiation
epidermal cell differentiation
regulation of translation
skin development
regulation of cellular amide metabolic process
epidermis development
regulation of cell growth
morphogenesis of an epithelium
supramolecular fiber organization
posttranscriptional regulation of gene expression
tissue morphogenesis