LAMP3

Gene Information

Official Symbol: LAMP3
Official Name: lysosomal associated membrane protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 27074
UniProt: Q9UQV4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in dendritic cell function and in adaptive immunity. {ECO:0000269|PubMed:9768752}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5867
Expression level (log2 read counts): 1.33

Expression Distribution

alveolar lamellar body membrane
response to interferon-alpha
negative regulation of proteasomal protein catabolic process
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cellular protein catabolic process
negative regulation of cysteine-type endopeptidase activity
viral entry into host cell
entry into host
entry into host cell
late endosome membrane
negative regulation of protein catabolic process
vesicle
regulation of viral life cycle
interaction with host
regulation of proteasomal protein catabolic process
viral life cycle
regulation of viral process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
negative regulation of peptidase activity
early endosome
lysosomal membrane
negative regulation of catabolic process
regulation of autophagy
negative regulation of proteolysis
regulation of protein catabolic process
regulation of endopeptidase activity
establishment of protein localization to organelle
regulation of peptidase activity
negative regulation of hydrolase activity
adaptive immune response
intracellular membrane-bounded organelle
perinuclear region of cytoplasm
viral process