LARP1 [The Human Chemical-Genetic Interaction Map Project]

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======= LARP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LARP1
  * **<color #00a2e8>Official Name</color>**: La ribonucleoprotein 1, translational regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23367|23367]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PKG0|Q6PKG0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LARP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LARP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612059|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669). Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:26735137}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|La|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to rapamycin|
|response to rapamycin|
|cellular response to ether|
|TORC1 complex|
|TORC1 signaling|
|eukaryotic initiation factor 4E binding|
|RNA cap binding|
|response to ether|
|RNA 7-methylguanosine cap binding|
|translation activator activity|
|ribosomal small subunit binding|
|negative regulation of translational initiation|
|translation initiation factor binding|
|mRNA 5-UTR binding|
|TOR signaling|
|polysomal ribosome|
|positive regulation of viral genome replication|
|mRNA stabilization|
|polysome|
|response to amino acid starvation|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|positive regulation of viral life cycle|
|cytoplasmic stress granule|
|positive regulation of macroautophagy|
|mRNA 3-UTR binding|
|negative regulation of mRNA metabolic process|
|regulation of translational initiation|
|cellular response to alcohol|
|cellular response to ketone|
|regulation of viral genome replication|
|response to antineoplastic agent|
|positive regulation of viral process|
|cellular response to antibiotic|
|positive regulation of autophagy|
|positive regulation of translation|
|negative regulation of translation|
|translational initiation|
|regulation of viral life cycle|
|negative regulation of cellular amide metabolic process|
|positive regulation of cellular amide metabolic process|
|regulation of macroautophagy|
|regulation of mRNA stability|
|regulation of RNA stability|
|response to starvation|
|response to ketone|
|regulation of mRNA catabolic process|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|response to alcohol|
|negative regulation of cellular catabolic process|
|response to antibiotic|
|negative regulation of catabolic process|
|cadherin binding|
|regulation of mRNA metabolic process|
|regulation of autophagy|
|regulation of translation|
|positive regulation of cellular catabolic process|
|translation|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|peptide biosynthetic process|
|positive regulation of catabolic process|
|response to nutrient levels|
|positive regulation of multi-organism process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|cell population proliferation|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of multi-organism process|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|response to organic cyclic compound|
|regulation of catabolic process|
|response to organonitrogen compound|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.01|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.79|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.7|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.73|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.76|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.85|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.88|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.01|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.04|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.04|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.14|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.16|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.33|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2118
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LARP1 Expression in NALM6 Cells: 9.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>