LARP1

Entrez Summary: N/A
UniProt Summary: RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669). Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:26735137}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.01
Olaparib 4μM R08 exp512	-1.79
Tubacin 1.6μM R07 exp416	1.7
5-Fluorouracil 20μM R00 exp2	1.73
Taxol 0.004μM R03 exp103	1.76
Rapamycin 10μM R00 exp30	1.85
Vemurafenib 6.6μM R08 exp434	1.88
Rapamycin 1μM R00 exp29	2.01
Calcium Ionophore 0.4μM R07 exp342	2.04
MK2206 4μM R08 exp504	2.04
Azithromycin 100μM R08 exp452	2.14
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.16
Dorsomorphin 5μM R07 exp357	2.33
Ibrutinib 10μM R08 exp442	2.54

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cellular response to rapamycin
response to rapamycin
cellular response to ether
TORC1 complex
TORC1 signaling
eukaryotic initiation factor 4E binding
RNA cap binding
response to ether
RNA 7-methylguanosine cap binding
translation activator activity
ribosomal small subunit binding
negative regulation of translational initiation
translation initiation factor binding
mRNA 5-UTR binding
TOR signaling
polysomal ribosome
positive regulation of viral genome replication
mRNA stabilization
polysome
response to amino acid starvation
RNA stabilization
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
positive regulation of viral life cycle
cytoplasmic stress granule
positive regulation of macroautophagy
mRNA 3-UTR binding
negative regulation of mRNA metabolic process
regulation of translational initiation
cellular response to alcohol
cellular response to ketone
regulation of viral genome replication
response to antineoplastic agent
positive regulation of viral process
cellular response to antibiotic
positive regulation of autophagy
positive regulation of translation
negative regulation of translation
translational initiation
regulation of viral life cycle