LEPROTL1

Entrez Summary: N/A
UniProt Summary: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:19907080}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

late endosome to vacuole transport via multivesicular body sorting pathway
negative regulation of protein localization to cell surface
late endosome to vacuole transport
endosome transport via multivesicular body sorting pathway
multivesicular body sorting pathway
regulation of protein localization to cell surface
negative regulation of cellular protein localization
vacuolar transport
endosomal transport
endosome
regulation of cellular protein localization
regulation of cellular localization
regulation of protein localization
intracellular transport
establishment of localization in cell
vesicle-mediated transport