LGALS1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= LGALS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LGALS1
  * **<color #00a2e8>Official Name</color>**: galectin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3956|3956]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09382|P09382]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LGALS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LGALS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/150570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24945728}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gal-bind lectin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of erythrocyte aggregation|
|regulation of erythrocyte aggregation|
|plasma cell differentiation|
|lactose binding|
|response to isolation stress|
|positive regulation of dendritic cell differentiation|
|positive regulation of homotypic cell-cell adhesion|
|positive regulation of viral entry into host cell|
|regulation of dendritic cell differentiation|
|mature B cell differentiation involved in immune response|
|laminin binding|
|mature B cell differentiation|
|regulation of homotypic cell-cell adhesion|
|regulation of viral entry into host cell|
|myoblast differentiation|
|B cell activation involved in immune response|
|response to axon injury|
|T cell costimulation|
|lymphocyte costimulation|
|positive regulation of viral life cycle|
|negative regulation of cell-substrate adhesion|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|intracellular|
|B cell differentiation|
|positive regulation of viral process|
|lymphocyte activation involved in immune response|
|response to glucose|
|response to hexose|
|regulation of viral life cycle|
|positive regulation of leukocyte differentiation|
|response to monosaccharide|
|negative regulation of neuron projection development|
|B cell activation|
|response to carbohydrate|
|carbohydrate binding|
|negative regulation of cell projection organization|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|regulation of viral process|
|regulation of cell-substrate adhesion|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of neuron differentiation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|lymphocyte differentiation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of neurogenesis|
|regulation of leukocyte cell-cell adhesion|
|endoplasmic reticulum lumen|
|negative regulation of nervous system development|
|regulation of T cell activation|
|leukocyte differentiation|
|negative regulation of cell development|
|positive regulation of lymphocyte activation|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of hemopoiesis|
|muscle structure development|
|regulation of neuron projection development|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|cellular response to organic cyclic compound|
|hemopoiesis|
|response to wounding|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cellular chemical homeostasis|
|regulation of multi-organism process|
|regulation of neurogenesis|
|protein homodimerization activity|
|cellular homeostasis|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|positive regulation of intracellular signal transduction|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|cell death|
|immune effector process|
|chemical homeostasis|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|RNA binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|neurogenesis|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.524|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8932
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LGALS1 Expression in NALM6 Cells: -0.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>