LGALS1
Gene Information
- Official Symbol: LGALS1
- Official Name: galectin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3956
- UniProt: P09382
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24945728}.
Pfam Domains GO Terms
Pfam Domains
| Gal-bind lectin |
GO Terms
| positive regulation of erythrocyte aggregation |
| regulation of erythrocyte aggregation |
| plasma cell differentiation |
| lactose binding |
| response to isolation stress |
| positive regulation of dendritic cell differentiation |
| positive regulation of homotypic cell-cell adhesion |
| positive regulation of viral entry into host cell |
| regulation of dendritic cell differentiation |
| mature B cell differentiation involved in immune response |
| laminin binding |
| mature B cell differentiation |
| regulation of homotypic cell-cell adhesion |
| regulation of viral entry into host cell |
| myoblast differentiation |
| B cell activation involved in immune response |
| response to axon injury |
| T cell costimulation |
| lymphocyte costimulation |
| positive regulation of viral life cycle |
| negative regulation of cell-substrate adhesion |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| cellular response to carbohydrate stimulus |
| cellular glucose homeostasis |
| intracellular |
| B cell differentiation |
| positive regulation of viral process |
| lymphocyte activation involved in immune response |
| response to glucose |
| response to hexose |
| regulation of viral life cycle |
| positive regulation of leukocyte differentiation |
| response to monosaccharide |
| negative regulation of neuron projection development |
| B cell activation |
| response to carbohydrate |
| carbohydrate binding |
| negative regulation of cell projection organization |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| glucose homeostasis |
| carbohydrate homeostasis |
| positive regulation of hemopoiesis |
| positive regulation of T cell activation |
| regulation of viral process |
| regulation of cell-substrate adhesion |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of symbiosis, encompassing mutualism through parasitism |
| negative regulation of neuron differentiation |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| lymphocyte differentiation |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| negative regulation of neurogenesis |
| regulation of leukocyte cell-cell adhesion |
| endoplasmic reticulum lumen |
| negative regulation of nervous system development |
| regulation of T cell activation |
| leukocyte differentiation |
| negative regulation of cell development |
| positive regulation of lymphocyte activation |
| post-translational protein modification |
| collagen-containing extracellular matrix |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| regulation of hemopoiesis |
| muscle structure development |
| regulation of neuron projection development |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| cellular response to organic cyclic compound |
| hemopoiesis |
| response to wounding |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| immune system development |
| regulation of neuron differentiation |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cellular chemical homeostasis |
| regulation of multi-organism process |
| regulation of neurogenesis |
| protein homodimerization activity |
| cellular homeostasis |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| positive regulation of intracellular signal transduction |
| response to drug |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell activation |
| cell death |
| immune effector process |
| chemical homeostasis |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of developmental process |
| RNA binding |
| generation of neurons |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| extracellular space |
| neurogenesis |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.524 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8932
- Expression level (log2 read counts): -0.81
Expression Distribution
LGALS1 Expression in NALM6 Cells: -0.81
