LGR5 [The Human Chemical-Genetic Interaction Map Project]

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======= LGR5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LGR5
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing G protein-coupled receptor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8549|8549]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75473|O75473]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LGR5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LGR5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606667|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|7tm 1|
|LRRNT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-hormone receptor activity|
|epithelial cell proliferation involved in renal tubule morphogenesis|
|G protein-coupled peptide receptor activity|
|activation of adenylate cyclase activity|
|oocyte differentiation|
|renal tubule morphogenesis|
|hair follicle development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|oogenesis|
|renal tubule development|
|epithelial cell proliferation|
|hair cycle|
|molting cycle|
|trans-Golgi network membrane|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|female gamete generation|
|transmembrane signaling receptor activity|
|positive regulation of canonical Wnt signaling pathway|
|cAMP-mediated signaling|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|positive regulation of Wnt signaling pathway|
|inner ear development|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|ear development|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|germ cell development|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|second-messenger-mediated signaling|
|cellular process involved in reproduction in multicellular organism|
|regulation of Wnt signaling pathway|
|skin development|
|epidermis development|
|morphogenesis of an epithelium|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|cellular response to hormone stimulus|
|tube morphogenesis|
|developmental process involved in reproduction|
|gamete generation|
|G protein-coupled receptor activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|response to hormone|
|multi-organism reproductive process|
|epithelium development|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8003
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LGR5 Expression in NALM6 Cells: 7.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>