LGR5

Entrez Summary: N/A
UniProt Summary: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein-hormone receptor activity
epithelial cell proliferation involved in renal tubule morphogenesis
G protein-coupled peptide receptor activity
activation of adenylate cyclase activity
oocyte differentiation
renal tubule morphogenesis
hair follicle development
skin epidermis development
hair cycle process
molting cycle process
oogenesis
renal tubule development
epithelial cell proliferation
hair cycle
molting cycle
trans-Golgi network membrane
adenylate cyclase-activating G protein-coupled receptor signaling pathway
female gamete generation
transmembrane signaling receptor activity
positive regulation of canonical Wnt signaling pathway
cAMP-mediated signaling
hormone-mediated signaling pathway
cyclic-nucleotide-mediated signaling
positive regulation of Wnt signaling pathway
inner ear development
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
ear development
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
germ cell development
regulation of canonical Wnt signaling pathway
renal system development
epithelial tube morphogenesis
urogenital system development
second-messenger-mediated signaling
cellular process involved in reproduction in multicellular organism
regulation of Wnt signaling pathway
skin development
epidermis development
morphogenesis of an epithelium
sensory organ development