LHX1 [The Human Chemical-Genetic Interaction Map Project]

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======= LHX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LHX1
  * **<color #00a2e8>Official Name</color>**: LIM homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3975|3975]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48742|P48742]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LHX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LHX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601999|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. {ECO:0000269|PubMed:9212161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oviduct epithelium development|
|dorsal spinal cord interneuron posterior axon guidance|
|uterine epithelium development|
|horizontal cell localization|
|nephric duct elongation|
|regulation of anterior head development|
|positive regulation of anterior head development|
|spinal cord interneuron axon guidance|
|cervix development|
|dorsal spinal cord interneuron axon guidance|
|oviduct development|
|positive regulation of nephron tubule epithelial cell differentiation|
|ectoderm formation|
|lateral motor column neuron migration|
|metanephric comma-shaped body morphogenesis|
|interneuron axon guidance|
|spinal cord motor neuron migration|
|paramesonephric duct development|
|metanephric part of ureteric bud development|
|metanephric S-shaped body morphogenesis|
|comma-shaped body morphogenesis|
|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|
|motor neuron migration|
|embryonic retina morphogenesis in camera-type eye|
|S-shaped body morphogenesis|
|ureter morphogenesis|
|anterior/posterior axon guidance|
|positive regulation of cerebellar granule cell precursor proliferation|
|positive regulation of epithelial cell differentiation involved in kidney development|
|positive regulation of gastrulation|
|mesonephric duct development|
|cerebellar Purkinje cell differentiation|
|pronephros development|
|cerebellar Purkinje cell layer formation|
|regulation of cerebellar granule cell precursor proliferation|
|mesendoderm development|
|embryonic viscerocranium morphogenesis|
|metanephric renal vesicle morphogenesis|
|vagina development|
|somite rostral/caudal axis specification|
|primitive streak formation|
|metanephric glomerulus development|
|nephric duct morphogenesis|
|renal vesicle morphogenesis|
|renal vesicle development|
|regulation of nephron tubule epithelial cell differentiation|
|cerebellar Purkinje cell layer morphogenesis|
|spinal cord association neuron differentiation|
|ureter development|
|nephric duct development|
|female genitalia development|
|positive regulation of branching involved in ureteric bud morphogenesis|
|regulation of epithelial cell differentiation involved in kidney development|
|cell differentiation in hindbrain|
|metanephric nephron morphogenesis|
|ectoderm development|
|positive regulation of mesonephros development|
|cerebellar cortex formation|
|regulation of branching involved in ureteric bud morphogenesis|
|uterus development|
|retina layer formation|
|dorsal spinal cord development|
|enhancer sequence-specific DNA binding|
|forebrain regionalization|
|regulation of mesonephros development|
|cerebellar Purkinje cell layer development|
|metanephros morphogenesis|
|motor neuron axon guidance|
|gastrulation with mouth forming second|
|cerebellar cortex morphogenesis|
|metanephric nephron development|
|positive regulation of morphogenesis of an epithelium|
|embryonic axis specification|
|positive regulation of embryonic development|
|regulation of gastrulation|
|cerebellum morphogenesis|
|positive regulation of kidney development|
|hindbrain morphogenesis|
|branching involved in ureteric bud morphogenesis|
|embryonic cranial skeleton morphogenesis|
|genitalia development|
|endoderm formation|
|cerebellar cortex development|
|ventral spinal cord development|
|retina morphogenesis in camera-type eye|
|anterior/posterior axis specification|
|glomerulus development|
|positive regulation of neural precursor cell proliferation|
|ureteric bud morphogenesis|
|cell differentiation in spinal cord|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|neural retina development|
|positive regulation of epithelial cell differentiation|
|embryonic pattern specification|
|nephron tubule morphogenesis|
|somitogenesis|
|nephron epithelium morphogenesis|
|cranial skeletal system development|
|nephron morphogenesis|
|renal tubule morphogenesis|
|endoderm development|
|nephron tubule development|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|dorsal/ventral pattern formation|
|somite development|
|metanephros development|
|kidney morphogenesis|
|axis specification|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|regulation of neural precursor cell proliferation|
|post-embryonic development|
|mesonephros development|
|embryonic skeletal system morphogenesis|
|segmentation|
|nephron epithelium development|
|cerebellum development|
|female sex differentiation|
|spinal cord development|
|cellular response to fibroblast growth factor stimulus|
|formation of primary germ layer|
|metencephalon development|
|camera-type eye morphogenesis|
|developmental growth involved in morphogenesis|
|response to fibroblast growth factor|
|neuron migration|
|nephron development|
|mesoderm development|
|embryonic skeletal system development|
|regulation of embryonic development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|retina development in camera-type eye|
|regulation of epithelial cell differentiation|
|eye morphogenesis|
|hindbrain development|
|gastrulation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|central nervous system neuron differentiation|
|regulation of morphogenesis of an epithelium|
|transcription factor complex|
|anterior/posterior pattern specification|
|skeletal system morphogenesis|
|transcription corepressor activity|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|sex differentiation|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|regionalization|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|forebrain development|
|developmental growth|
|growth|
|axon development|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|neuron projection morphogenesis|
|transcription by RNA polymerase II|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|response to growth factor|
|positive regulation of nervous system development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|protein-containing complex|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|neuron projection development|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.75|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.85|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10099
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LHX1 Expression in NALM6 Cells: -1.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>