LHX1
Gene Information
- Official Symbol: LHX1
- Official Name: LIM homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3975
- UniProt: P48742
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. {ECO:0000269|PubMed:9212161}.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
| LIM |
GO Terms
| oviduct epithelium development |
| dorsal spinal cord interneuron posterior axon guidance |
| uterine epithelium development |
| horizontal cell localization |
| nephric duct elongation |
| regulation of anterior head development |
| positive regulation of anterior head development |
| spinal cord interneuron axon guidance |
| cervix development |
| dorsal spinal cord interneuron axon guidance |
| oviduct development |
| positive regulation of nephron tubule epithelial cell differentiation |
| ectoderm formation |
| lateral motor column neuron migration |
| metanephric comma-shaped body morphogenesis |
| interneuron axon guidance |
| spinal cord motor neuron migration |
| paramesonephric duct development |
| metanephric part of ureteric bud development |
| metanephric S-shaped body morphogenesis |
| comma-shaped body morphogenesis |
| cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation |
| motor neuron migration |
| embryonic retina morphogenesis in camera-type eye |
| S-shaped body morphogenesis |
| ureter morphogenesis |
| anterior/posterior axon guidance |
| positive regulation of cerebellar granule cell precursor proliferation |
| positive regulation of epithelial cell differentiation involved in kidney development |
| positive regulation of gastrulation |
| mesonephric duct development |
| cerebellar Purkinje cell differentiation |
| pronephros development |
| cerebellar Purkinje cell layer formation |
| regulation of cerebellar granule cell precursor proliferation |
| mesendoderm development |
| embryonic viscerocranium morphogenesis |
| metanephric renal vesicle morphogenesis |
| vagina development |
| somite rostral/caudal axis specification |
| primitive streak formation |
| metanephric glomerulus development |
| nephric duct morphogenesis |
| renal vesicle morphogenesis |
| renal vesicle development |
| regulation of nephron tubule epithelial cell differentiation |
| cerebellar Purkinje cell layer morphogenesis |
| spinal cord association neuron differentiation |
| ureter development |
| nephric duct development |
| female genitalia development |
| positive regulation of branching involved in ureteric bud morphogenesis |
| regulation of epithelial cell differentiation involved in kidney development |
| cell differentiation in hindbrain |
| metanephric nephron morphogenesis |
| ectoderm development |
| positive regulation of mesonephros development |
| cerebellar cortex formation |
| regulation of branching involved in ureteric bud morphogenesis |
| uterus development |
| retina layer formation |
| dorsal spinal cord development |
| enhancer sequence-specific DNA binding |
| forebrain regionalization |
| regulation of mesonephros development |
| cerebellar Purkinje cell layer development |
| metanephros morphogenesis |
| motor neuron axon guidance |
| gastrulation with mouth forming second |
| cerebellar cortex morphogenesis |
| metanephric nephron development |
| positive regulation of morphogenesis of an epithelium |
| embryonic axis specification |
| positive regulation of embryonic development |
| regulation of gastrulation |
| cerebellum morphogenesis |
| positive regulation of kidney development |
| hindbrain morphogenesis |
| branching involved in ureteric bud morphogenesis |
| embryonic cranial skeleton morphogenesis |
| genitalia development |
| endoderm formation |
| cerebellar cortex development |
| ventral spinal cord development |
| retina morphogenesis in camera-type eye |
| anterior/posterior axis specification |
| glomerulus development |
| positive regulation of neural precursor cell proliferation |
| ureteric bud morphogenesis |
| cell differentiation in spinal cord |
| mesonephric tubule morphogenesis |
| regulation of kidney development |
| regulation of morphogenesis of a branching structure |
| neural retina development |
| positive regulation of epithelial cell differentiation |
| embryonic pattern specification |
| nephron tubule morphogenesis |
| somitogenesis |
| nephron epithelium morphogenesis |
| cranial skeletal system development |
| nephron morphogenesis |
| renal tubule morphogenesis |
| endoderm development |
| nephron tubule development |
| renal tubule development |
| positive regulation of animal organ morphogenesis |
| dorsal/ventral pattern formation |
| somite development |
| metanephros development |
| kidney morphogenesis |
| axis specification |
| ureteric bud development |
| mesonephric tubule development |
| mesonephric epithelium development |
| regulation of neural precursor cell proliferation |
| post-embryonic development |
| mesonephros development |
| embryonic skeletal system morphogenesis |
| segmentation |
| nephron epithelium development |
| cerebellum development |
| female sex differentiation |
| spinal cord development |
| cellular response to fibroblast growth factor stimulus |
| formation of primary germ layer |
| metencephalon development |
| camera-type eye morphogenesis |
| developmental growth involved in morphogenesis |
| response to fibroblast growth factor |
| neuron migration |
| nephron development |
| mesoderm development |
| embryonic skeletal system development |
| regulation of embryonic development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| retina development in camera-type eye |
| regulation of epithelial cell differentiation |
| eye morphogenesis |
| hindbrain development |
| gastrulation |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| central nervous system neuron differentiation |
| regulation of morphogenesis of an epithelium |
| transcription factor complex |
| anterior/posterior pattern specification |
| skeletal system morphogenesis |
| transcription corepressor activity |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| sex differentiation |
| kidney development |
| renal system development |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| camera-type eye development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| urogenital system development |
| regionalization |
| eye development |
| visual system development |
| sensory system development |
| axonogenesis |
| forebrain development |
| developmental growth |
| growth |
| axon development |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| neuron projection morphogenesis |
| transcription by RNA polymerase II |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| skeletal system development |
| cellular response to growth factor stimulus |
| cell part morphogenesis |
| response to growth factor |
| positive regulation of nervous system development |
| sensory organ development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| protein-containing complex |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| neuron projection development |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| tube development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| neuron differentiation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pyrazinamide 100μM R08 exp516 | 1.75 |
| DKK1 89ng/ml R08 exp477 | 1.85 |
| 5-Fluorouracil 20μM R00 exp2 | 2.04 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10099
- Expression level (log2 read counts): -1.82
Expression Distribution
LHX1 Expression in NALM6 Cells: -1.82
