LHX5 [The Human Chemical-Genetic Interaction Map Project]

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======= LHX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LHX5
  * **<color #00a2e8>Official Name</color>**: LIM homeobox 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64211|64211]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2C1|Q9H2C1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LHX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LHX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605992|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|
|positive regulation of cerebellar granule cell precursor proliferation|
|cerebellar Purkinje cell differentiation|
|cerebellar Purkinje cell layer formation|
|regulation of cerebellar granule cell precursor proliferation|
|spinal cord association neuron differentiation|
|cerebellar Purkinje cell layer morphogenesis|
|cell differentiation in hindbrain|
|cerebellar cortex formation|
|dorsal spinal cord development|
|cerebellar Purkinje cell layer development|
|cell proliferation in forebrain|
|cerebellar cortex morphogenesis|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|cerebellar cortex development|
|forebrain neuron differentiation|
|positive regulation of neural precursor cell proliferation|
|cell differentiation in spinal cord|
|forebrain generation of neurons|
|neural precursor cell proliferation|
|hippocampus development|
|regulation of neural precursor cell proliferation|
|cerebellum development|
|spinal cord development|
|limbic system development|
|metencephalon development|
|hindbrain development|
|pallium development|
|central nervous system neuron differentiation|
|telencephalon development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|forebrain development|
|positive regulation of nervous system development|
|cell population proliferation|
|brain development|
|head development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|central nervous system development|
|neuron differentiation|
|cell-cell signaling|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.79|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LHX5 Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>