LHX5

Gene Information

Official Symbol: LHX5
Official Name: LIM homeobox 5
Aliases and Previous Symbols: N/A
Entrez ID: 64211
UniProt: Q9H2C1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15140
Expression level (log2 read counts): -2.69

Expression Distribution

Screen	Score
Losmapimod 1μM R07 exp376	-1.79
Benzoate 10000μM R08 exp455	2.03

LIM
Homeobox

cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
positive regulation of cerebellar granule cell precursor proliferation
cerebellar Purkinje cell differentiation
cerebellar Purkinje cell layer formation
regulation of cerebellar granule cell precursor proliferation
spinal cord association neuron differentiation
cerebellar Purkinje cell layer morphogenesis
cell differentiation in hindbrain
cerebellar cortex formation
dorsal spinal cord development
cerebellar Purkinje cell layer development
cell proliferation in forebrain
cerebellar cortex morphogenesis
cerebellum morphogenesis
hindbrain morphogenesis
cerebellar cortex development
forebrain neuron differentiation
positive regulation of neural precursor cell proliferation
cell differentiation in spinal cord
forebrain generation of neurons
neural precursor cell proliferation
hippocampus development
regulation of neural precursor cell proliferation
cerebellum development
spinal cord development
limbic system development
metencephalon development
hindbrain development
pallium development
central nervous system neuron differentiation
telencephalon development
RNA polymerase II regulatory region sequence-specific DNA binding
forebrain development
positive regulation of nervous system development
cell population proliferation
brain development
head development
anatomical structure formation involved in morphogenesis
positive regulation of cell population proliferation
regulation of nervous system development