LIMS1
Gene Information
- Official Symbol: LIMS1
- Official Name: LIM zinc finger domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3987
- UniProt: P48059
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
Pfam Domains GO Terms
Pfam Domains
| LIM |
GO Terms
| positive regulation of integrin-mediated signaling pathway |
| regulation of integrin-mediated signaling pathway |
| positive regulation of focal adhesion assembly |
| positive regulation of adherens junction organization |
| positive regulation of cell junction assembly |
| positive regulation of substrate adhesion-dependent cell spreading |
| positive regulation of cell-matrix adhesion |
| regulation of substrate adhesion-dependent cell spreading |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| cell aging |
| regulation of adherens junction organization |
| epithelial to mesenchymal transition |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of cell junction assembly |
| protein heterooligomerization |
| regulation of NIK/NF-kappaB signaling |
| regulation of cell-matrix adhesion |
| tumor necrosis factor-mediated signaling pathway |
| positive regulation of cell-substrate adhesion |
| cell-cell junction organization |
| cellular response to transforming growth factor beta stimulus |
| positive regulation of cell morphogenesis involved in differentiation |
| mesenchymal cell differentiation |
| response to transforming growth factor beta |
| cell junction assembly |
| cell-cell junction |
| regulation of cell-substrate adhesion |
| cell junction organization |
| mesenchyme development |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| aging |
| regulation of cell morphogenesis involved in differentiation |
| regulation of epithelial cell proliferation |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| focal adhesion |
| protein kinase binding |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| cellular response to growth factor stimulus |
| cell-cell adhesion |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| response to growth factor |
| positive regulation of cell development |
| protein-containing complex |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| perinuclear region of cytoplasm |
| positive regulation of hydrolase activity |
| zinc ion binding |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| regulation of anatomical structure morphogenesis |
| response to cytokine |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| establishment of protein localization |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| negative regulation of gene expression |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BN82002 4μM R07 exp340 | 1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 4/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17670
- Expression level (log2 read counts): 5.89
Expression Distribution
LIMS1 Expression in NALM6 Cells: 5.89
