LMAN2L
Gene Information
- Official Symbol: LMAN2L
- Official Name: lectin, mannose binding 2 like
- Aliases and Previous Symbols: N/A
- Entrez ID: 81562
- UniProt: Q9H0V9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016].
- UniProt Summary: May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53. {ECO:0000269|PubMed:12878160}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7271
- Expression level (log2 read counts): 4.78
LMAN2L Expression in NALM6 Cells: 4.78
