LMOD2

Entrez Summary: N/A
UniProt Summary: Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:26370058, PubMed:25250574, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713). {ECO:0000250|UniProtKB:Q3UHZ5, ECO:0000269|PubMed:18403713, ECO:0000269|PubMed:25250574, ECO:0000269|PubMed:26370058, ECO:0000269|PubMed:26417072}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pointed-end actin filament capping
tropomyosin binding
striated muscle thin filament
actin monomer binding
M band
myofibril
actin filament polymerization
actin nucleation
actin filament capping
negative regulation of actin filament depolymerization
sarcomere organization
sarcomere
actin polymerization or depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
negative regulation of protein polymerization
myofibril assembly
negative regulation of protein complex disassembly
actin filament
regulation of protein depolymerization
protein polymerization
positive regulation of actin filament polymerization
cellular component assembly involved in morphogenesis
regulation of protein complex disassembly
actomyosin structure organization
positive regulation of protein polymerization
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
striated muscle cell development
negative regulation of cytoskeleton organization
muscle cell development
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
striated muscle cell differentiation
positive regulation of cytoskeleton organization
regulation of protein polymerization
actin filament organization