LMX1A

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
LIM

olfactory behavior
midbrain dopaminergic neuron differentiation
dentate gyrus development
chemosensory behavior
dopaminergic neuron differentiation
hippocampus development
midbrain development
cerebellum development
limbic system development
metencephalon development
memory
hindbrain development
pallium development
central nervous system neuron differentiation
locomotory behavior
negative regulation of neuron differentiation
telencephalon development
learning or memory
axon guidance
neuron projection guidance
synapse organization
negative regulation of neurogenesis
cognition
negative regulation of nervous system development
RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of cell development
axonogenesis
forebrain development
axon development
regulation of cell growth
cell morphogenesis involved in neuron differentiation
DNA-binding transcription activator activity, RNA polymerase II-specific
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
behavior