LPAR1

Gene Information

Official Symbol: LPAR1
Official Name: lysophosphatidic acid receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 1902
UniProt: Q92633
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7810
Expression level (log2 read counts): -4.6

Expression Distribution

Screen	Score
MKC9989 10μM R03 exp133	-1.83
Zebularine 20μM R07 exp423	1.71
Diepoxybutane 3μM R07 exp354	1.84

response to 1-oleoyl-sn-glycerol 3-phosphate
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
lysophosphatidic acid receptor activity
positive regulation of smooth muscle cell chemotaxis
lysophosphatidic acid binding
regulation of smooth muscle cell chemotaxis
bleb assembly
optic nerve development
corpus callosum development
negative regulation of cAMP-mediated signaling
G-protein alpha-subunit binding
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
activation of phospholipase C activity
dendritic shaft
positive regulation of smooth muscle cell migration
oligodendrocyte development
positive regulation of phospholipase C activity
positive regulation of dendritic spine development
regulation of phospholipase C activity
regulation of cAMP-mediated signaling
cranial nerve development
positive regulation of stress fiber assembly
endocytic vesicle
positive regulation of phospholipase activity
regulation of smooth muscle cell migration
positive regulation of actin filament bundle assembly
positive regulation of Ras protein signal transduction
oligodendrocyte differentiation
positive regulation of lipase activity
regulation of phospholipase activity
positive regulation of small GTPase mediated signal transduction
regulation of dendritic spine development
positive regulation of dendrite development
nerve development
regulation of stress fiber assembly
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
PDZ domain binding
regulation of actomyosin structure organization
regulation of actin filament bundle assembly