LRAT

Entrez Summary: The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
UniProt Summary: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. {ECO:0000269|PubMed:9920938}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylcholine-retinol O-acyltransferase activity
O-palmitoyltransferase activity
lecithin:11-cis retinol acyltransferase activity
vitamin A metabolic process
retinol binding
response to vitamin A
transferase activity, transferring acyl groups
retinoic acid binding
multivesicular body
fat-soluble vitamin metabolic process
retinol metabolic process
rough endoplasmic reticulum
positive regulation of lipid transport
primary alcohol metabolic process
positive regulation of lipid localization
response to vitamin
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
retinoid metabolic process
regulation of lipid transport
response to retinoic acid
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
vitamin metabolic process
regulation of lipid localization
isoprenoid metabolic process
hormone metabolic process
response to nutrient
visual perception
sensory perception of light stimulus
alcohol metabolic process
response to acid chemical
organic hydroxy compound metabolic process
response to nutrient levels
response to extracellular stimulus
regulation of hormone levels
response to bacterium
perinuclear region of cytoplasm
response to lipid