LRBA
Gene Information
- Official Symbol: LRBA
- Official Name: LPS responsive beige-like anchor protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 987
- UniProt: P50851
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
- UniProt Summary: May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7333
- Expression level (log2 read counts): 7.35
LRBA Expression in NALM6 Cells: 7.35
