LRFN5

Official Symbol: LRFN5
Official Name: leucine rich repeat and fibronectin type III domain containing 5
Aliases and Previous Symbols: N/A
Entrez ID: 145581
UniProt: Q96NI6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016].
UniProt Summary: Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. {ECO:0000269|PubMed:18227064, ECO:0000269|PubMed:18585462}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LRR 4
I-set

negative regulation of macrophage activation
synaptic membrane adhesion
regulation of presynapse assembly
regulation of presynapse organization
integral component of postsynaptic density membrane
regulation of macrophage activation
GABA-ergic synapse
regulation of synapse assembly
negative regulation of inflammatory response
negative regulation of leukocyte activation
negative regulation of cell activation
negative regulation of defense response
regulation of synapse organization
regulation of synapse structure or activity
cell-cell adhesion via plasma-membrane adhesion molecules
synapse organization
regulation of inflammatory response
glutamatergic synapse
negative regulation of response to external stimulus
negative regulation of immune system process
cell-cell adhesion
regulation of leukocyte activation
cell surface
regulation of cell activation
regulation of defense response
regulation of nervous system development
cell adhesion
biological adhesion
regulation of cellular component biogenesis
regulation of response to external stimulus
regulation of response to stress
negative regulation of response to stimulus
regulation of immune system process