LRIG1

Entrez Summary: N/A
UniProt Summary: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.03
CB-5083 0.4μM R08 exp468	-1.81
Isonicotinamide 500μM R03 exp129	1.77
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

otolith morphogenesis
otolith development
innervation
hair cycle process
molting cycle process
nerve development
hair cycle
molting cycle
inner ear morphogenesis
ear morphogenesis
sensory perception of sound
sensory perception of mechanical stimulus
inner ear development
ear development
extracellular matrix
sensory organ morphogenesis
embryonic organ morphogenesis
embryonic organ development
sensory organ development
embryonic morphogenesis
animal organ morphogenesis
sensory perception
embryo development
nervous system process
extracellular space
system process