LRRC17

Entrez Summary: N/A
UniProt Summary: Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

osteoblast proliferation
bone marrow development
negative regulation of osteoclast differentiation
negative regulation of myeloid leukocyte differentiation
regulation of osteoclast differentiation
negative regulation of myeloid cell differentiation
negative regulation of leukocyte differentiation
regulation of myeloid leukocyte differentiation
osteoblast differentiation
negative regulation of hemopoiesis
bone development
regulation of myeloid cell differentiation
extracellular matrix
ossification
regulation of leukocyte differentiation
negative regulation of immune system process
regulation of hemopoiesis
skeletal system development
cell population proliferation
hematopoietic or lymphoid organ development
immune system development
negative regulation of cell differentiation
negative regulation of developmental process
negative regulation of multicellular organismal process
extracellular space
regulation of immune system process
tissue development
regulation of cell differentiation