LRRTM1

Entrez Summary: N/A
UniProt Summary: Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of postsynaptic density assembly
negative regulation of receptor internalization
regulation of postsynapse assembly
regulation of postsynaptic specialization assembly
regulation of excitatory synapse assembly
regulation of postsynaptic density organization
negative regulation of receptor-mediated endocytosis
integral component of postsynaptic specialization membrane
exploration behavior
regulation of presynapse assembly
regulation of presynapse organization
excitatory synapse
negative regulation of endocytosis
long-term synaptic potentiation
regulation of receptor internalization
protein localization to synapse
positive regulation of synapse assembly
GABA-ergic synapse
regulation of postsynapse organization
regulation of receptor-mediated endocytosis
regulation of synapse assembly
growth cone
positive regulation of synaptic transmission
regulation of synaptic plasticity
locomotory behavior
regulation of endocytosis
regulation of synapse organization
regulation of organelle assembly
regulation of synapse structure or activity
extracellular matrix
synapse organization
axon
glutamatergic synapse
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
negative regulation of transport
positive regulation of cellular component biogenesis
positive regulation of nervous system development
cell junction
regulation of vesicle-mediated transport