LSM2

Official Symbol: LSM2
Official Name: LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Aliases and Previous Symbols: N/A
Entrez ID: 57819
UniProt: Q9Y333
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Lsm1-7-Pat1 complex
Lsm2-8 complex
U6 snRNP
U6 snRNA binding
Ral GTPase binding
U4/U6 x U5 tri-snRNP complex
exonucleolytic catabolism of deadenylated mRNA
nuclear-transcribed mRNA catabolic process, exonucleolytic
U2-type precatalytic spliceosome
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
catalytic step 2 spliceosome
P-body
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
nucleobase-containing compound catabolic process
RNA splicing
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
mRNA processing
organic cyclic compound catabolic process
mRNA metabolic process
RNA processing
cellular macromolecule catabolic process
macromolecule catabolic process
RNA binding
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process
gene expression