LTBP1

Gene Information

Official Symbol: LTBP1
Official Name: latent transforming growth factor beta binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 4052
UniProt: Q14766
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8840
Expression level (log2 read counts): -5.6

Expression Distribution

TB
cEGF
EGF CA

microfibril binding
sequestering of TGFbeta in extracellular matrix
maintenance of protein location in extracellular region
regulation of transforming growth factor beta activation
sequestering of extracellular ligand from receptor
microfibril
extracellular negative regulation of signal transduction
extracellular regulation of signal transduction
transforming growth factor beta-activated receptor activity
transforming growth factor beta binding
regulation of transforming growth factor beta production
coronary vasculature development
aorta development
ventricular septum development
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
artery development
maintenance of protein location
cardiac septum development
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
cardiac ventricle development
extracellular matrix structural constituent
negative regulation of cellular response to growth factor stimulus
maintenance of location
protein localization to extracellular region
cardiac chamber development
transmembrane receptor protein serine/threonine kinase signaling pathway
extracellular matrix
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
endoplasmic reticulum lumen
post-translational protein modification
collagen-containing extracellular matrix
blood vessel development
vasculature development
cardiovascular system development
heart development
protein-containing complex