LUC7L2 [The Human Chemical-Genetic Interaction Map Project]

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======= LUC7L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LUC7L2
  * **<color #00a2e8>Official Name</color>**: LUC7 like 2, pre-mRNA splicing factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51631|51631]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y383|Q9Y383]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LUC7L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LUC7L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613056|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May bind to RNA via its Arg/Ser-rich domain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LUC7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type prespliceosome|
|U1 snRNP|
|mRNA splice site selection|
|spliceosomal complex assembly|
|mRNA binding|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|enzyme binding|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-3.23|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.79|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.28|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.2|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.18|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.14|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.14|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.94|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.87|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.86|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.76|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.75|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.73|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.72|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.71|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.7|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.7|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.7|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.73|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.82|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.02|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2672
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LUC7L2 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>